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В результате работы экспертного совета общероссийского конкурса Ассоциации книгоиздателей «Лучшие книги года-2022» по номинации "Лучшее учебное издание для высшей школы" в лонг-лист изданий вошла книга «Основы теории структурной оптимизации систем контроля и управления беспилотными летательными аппаратами» АО "Издательство "Политехника", г.Санкт-Петербург.

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Вниманию историков - студентов, аспирантов, молодых ученых!

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Metalloobrabotka № 3 (75)/2013Книга 1. Машиностроение. Корабли и суда | Томашевский В. Т., Пашин В. М., Захаров И.Г. и др

Biotekhnosfera № 3/2017

Biotekhnosfera № 3/2017
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Цена: 700 Руб.


Instrument Making, Metrology and Information Measuring Devices and Systems

Ilin S. Yu., Luchinin V. V. Epidermal biointegrable personalized intelligent sensory and corrective micro- and nanosystems

Modern state and prospects of development of epidermal biointegrated personalized intelligent sensory and correcting micro- and nanosystems, epidermically placed directly on the surface of the skin and co-operable with constructive clothing elements, are considered. Structural and technological solutions based on flexible printed electronics and photonics are presented, which are the most progressive in the field of formation of the modern intellectual personified biotechnosphere.

Keywords: biointegrated personified intelligent micro-and nanosystems, intellectual artificial skin, interactive multifunctional platform, electronic skin, photonic skin, epidermal monitoring, transepidermal correction.

Lemozersky V. E., Zimina T. M., Koigerov A. S., Khait O. V. Development of the electroacoustic actuator module integrated with microfluidic system for express preparation of blood fractions

The article discusses the prospects of using an electroacoustic element integrated with microfluidic system for the separation of blood fractions for use in hematology. A method for calculating and constructing a microdevice is described. The data of its testing are given. The possibility of achieving a performance of 0,5 ml per minute for one separation channel is shown.

Keywords: electroacoustics, sensor-actuator elements, separation of blood cells.

Semenov A. I., Zimina T. M., Soloviev A. V. Study of bacteria identification possibility using acoustic sensor based on quarts resonator

In this article the application of a quartz resonator based acoustic sensor for differentiation of gram-positive and gram-negative bacteria have been considered through the example of E. Coli M-17 and Lactobacillus fermentum 90T-C4.

Keywords: acoustic sensor, laboratory-on-a-chip, gram-positive and gram-negative bacteria.

Sitkov N. O., Zimina T. M., Soloviev A. V., Kraeva L. A. Miniature sensor element integratable into laboratory-on-a-chip based on electrical impedance for evaluation of antibiotic susceptibility of microorganisms

A miniature impedimetric sensor element integratable into a laboratory-on-chip for testing antibiotic-susceptibility of microorganisms is described. The topology, design and manufacturing technology of impedimetric measuring chips comprising a sensor element based on interdigital electrodes are discussed. With the help of a sample of chips, measurements were made on the evaluation of antibiotic resistance (ADB) of microorganisms, under the influence of a number of antibiotics. The possibility of using the developed sensor element for ADB estimation at the exposure time of 1 to 3 hours has been shown experimentally. The concentration limit of sensitivity of the sensor element being developed is determined. Frequency dependences of the electrical impedance for E. coli strain M-17 with various antimicrobial agents were obtained. The presence of sensitivity in the investigated bacterial type to ceftazidime and ceftriaxone has been experimentally confirmed, as well as a lack of sensitivity to benzylpenicillin. A numerical parameter is proposed for assessing the degree of antibiotic exposure to a microorganism.

Keywords: laboratory-on-chip, impedimetric sensors, microorganisms, antibiotic resistance.

Egorov A. I., Zimina T. M., Karasev V. A., Kolobov А. A. Matrix peptide biosensory systems based on molecular recognition for express diagnostics of diseases

The article deals with biosensor systems for express diagnostics based on molecular biorecognition using peptide micro-matrices (PMM). The ways of PMM design on the basis of synthetic peptide ligands (aptamers) are investigated. The problems of diagnostics of diseases are considered and the priorities for applying molecular biorecognition principles using synthetic peptide nanoligands are set. The principles of functioning and technology of biochip formation are discussed. By molecular 3D-design methods, sequences were found and peptide aptamers were synthesized. Their interaction with the target proteins, using troponin as an example, by the method of capillary electrophoresis on a chip was studied using the Experion system (Bio-Rad, USA) and a 10-channel microfluidic chip Pro260. The selectivity of synthesized peptide ap-tamers to target protein biomarker – troponin T has been experimentally demonstrated.

Keywords: molecular biorecognition, aptamers, biomarkers, selectivity, laboratory-on-chip, diagnostics of diseases.

Nanotechnology and Nanomaterials

Aleksandrova O. A., Drobintseva A. O., Kvetnoy I. M., Krylova Yu. S., Mazing D. S., Matyushkin L. B., Moshnikov V. A., Musikhin S. F., Polyakova V. O. Fluorescent colloidal quantum dot based probes for p53 and CD34 markers

According to clinical observations increased expression of the nuclear protein p53 and the membrane protein CD34 is a sign of malignant tumor development.The colloidal quantum dots of cadmium selenide were conjugated to monoclonal antibodies to p53 and CD34 proteins by the carbodiimide method. Theinvestigation conducted on both the cell culture and the pancreatic tissue confirmed the penetration of CdSe/p53-AT complexes into cells and specific reaction with p53.

Keywords: laser-scanning optical microscopy, colloidal quantum dots, fluorophores, immunofluorescence analysis, protein p53, protein CD34.

Gareev K. G., Babikova K. Y., Naumisheva E. B., Postnov V. N., Korolev D. V. Synthesis of nanomaterials with a fluorescent label for medical purposes

A comparative study of silica, magnetite and magnetitesilica nanoparticles modified with fluorescent dyes with gas-phase and liquid-phase methods was carried out. Analysis of the shape and size of nanoparticles before and after amination showed that the morphology of the nanoparticles does not change significantly, while the 3-aminopropyltriethoxysilane used to modify the surface forms a thin layer that could not be detected with transmission electron microscopy. With a comparable content of a fluorescent dye, determined spectrophotometrically, nanoparticles with fluorescein have times the total light output up to 1000 higher. It was found that magnetic nanoparticles are characterized by lower light output than silica particles, while magnetite particles are most effective when modifying with fluorescein, and magnetite-silica particles are modified with indocyanine green. The highest light output was obtained with silica nanoparticles, modified with fluorescein using a carbodiimide method.

Keywords: magnetic nanoparticles, biomedicine, iron oxide, silica, fluorescent label, indocyanine green, fluorescein, liquid phase amination, gas phase amination.

Spivak Y. M., Bespalova K. A., Belorus A. O., Panevin A. A., Somov P. A., Grigoryeva N. Yu., Chistyakova L. V., Zhuravskii S. G., Moshnikov V. A. Obtaining and medicinal functionalization of porous silicon nanoparticles

Particles of porous silicon, functionalized with antibiotic kanamycin sulfate, were obtained and studied. The toxicity of por-Si particles against unicellular organisms was assessed. There are revealed the features of insertion the molecules of kanamycin sulfate and indocyanine green on por-Si surfaces by methods of impregnation and electrophoretic deposition. It is shown that the choice of technological conditions for obtaining a certain composition of functional groups on the por-Si surface is the key for the targeted functionalization. The possibility of biodistribution of the resulting por-Si particles to various organs in vivo is shown.

Keywords: targeted drug delivery, porous carrier matrices, porous silicon nanoparticles, medicament functionalization, electrophoresis deposition, impregnation, functional surface composition, electrochemical anodic dissolution, UVspectrophotometry, confocal microspectroscopy, biodistribution.

Gareev K. G., Pugach V. S., Evreinova N. V., Naumisheva E. B., Panov M. F., Korolev D. V. Development of magnetic nanoparticles’ surface modification methods with saccharide protective shell

Magnetic nanoparticles based on iron oxides are used for targeted drug delivery, and therefore must have high aggregative stability and good magnetic characteristics. In this paper, a comparative study was made of the possibility of coating magnetic nanoparticles with a protective shell of polysaccharides with the hydrothermal method. Nanoparticles of three types were investigated: magnetite, magnetite-silica, and also particles obtained directly with the hydrothermal method in a mini-autoclave. It was shown that magnetite nanoparticles coated with a carbohydrate shell do not form aggregates, unlike magnetite-silica nanoparticles. The presence of carbohydrate shell on the surface of nanoparticles was additionally confirmed on the basis of analysis of the spectra of infrared Fourier spectroscopy. Measurements of the magnetic characteristics of the modified nanoparticles made it possible to recommend magnetite-silica nanoparticles as a magnetically controlled delivery if long circulation of nanoparticles in the bloodstream is not required and there is no risk of thromboembolism at aggregate sizes of the order of 100 nm.

Keywords: magnetic nanoparticles, biomedicine, polysaccharides, iron oxide, silica, hydrothermal synthesis.

Anchkov M. G. The analysis of multilevel memristor of logical element as a basis of neuromorphic computer environment

The article describes the development of physicomathematical model of memristor multilevel gate. The processes in gate structures were considered. And the available model of switching states in multilevel gates presented. The availability of memristor matrix as the gate of processing and transformation of information is argumented.

Keywords: memristor, memory cell, multilevel resistive switching, Hopfield network.