Biotekhnosfera № 3/2014

Materials of Russia-German conference on Biomedical Engineering

Ilyin S. Yu., Luchinin V. V. Flexible Photonics in the technological evolution of human habitat

Review provides a system of scientific-technological and industrial aesthetic solutions in the field of Photonics flexible in regard to the decision of problems of artificial and natural lighting, lighting control and heat transfer, as well as the conversion of solar energy in a traditional human habitat (private dwellings, public and industrial buildings, vehicles).

Keywords: flexible electronics, photonics, paper roll, stencil, drip-ink technologies, organic sources of illumination, glass managed options, sources of solar energy.

Alexandrov P. L., Gradov O. V. Conventional patch-clamp techniques for multi-channel Lab-On-A-Chip signal registration using real time target machine interfaces and in situ real-time digital signal processing

The need for simultaneous data recording from multiple channels and synchronization of correlation data processing in conventional patch-clamp on microelectrode arrays / chips with many data capture points corresponding to single channel ionic kinetic processes of individual cells leads to the idea that adaptive variation of the local potential registration conditions in multichannel devices without signal preprocessing in real time is impossible. Moreover, the advisability of direct registration coupling with the model realization for kinetic identification of the process during patch-clamp can be realized only in case of their synchronization. We propose here such a measurement system.

Keywords: patch-klamp, ionic channels, the SIMULINK REAL-TIME technology, laboratory on the chip, the car of real time, screening.

Gryaznov A. Yu., Gamova K. K., Bessonov V. В., Livshits O. A., Kunasek E. S. The method of obtaining false-color x-ray image in two-energy radiography

The article describes the method of formation of the pseudo-color x-ray images. It is shown that the use two-energy exposure allows to significantly facilitate the work of the radiologist, increasing the information content of the images and allowing analysis with much less chance of errors.

Keywords: pseudo-color image, color space, x-ray image.

Ilyasova N. Yu. The diagnostic complex image analysis vascular fundus

The article presents the diagnostic complex for blood vessels' analysis of the eye fundus images. This complex intends for clinical vascular pathology research at early stages of diabetic retinopathy. A diagnostic features efficiency analysis for blood vessels classification in norm and l-to-4 grade of diabetes mellitus is presented. The vascular features statistical efficiency analysis was employed for new features development to improve the quality of classification.

Keywords: retina, blood-vessel image processing.

Nasonova A. A., Krylov A. S. Blood vessel detection with quality estimation in eye fundus images

In this work we present a new method of blood vessel detection that consists of image preprocessing and vessel detection itself. Preprocessing is aimed at accentuation of the blood vessels and consists of luminosity stabilization, removal of other retinal details using a morphological alternating sequential filtering, vessel enhancement using Gabor filtering. In this work we also propose a new metric for vessel segmentation quality estimation that compares the result of the automatic vessel detection to a ground truth vessel map created by a specialist manually.
Keywords: blood-vessel detection, fundus image, metric, quality estimation.
Isakov R. V. Methodology mining kardiosignalas
This article summarizes the results of the development of intelligent systems for rapid assessment of the functional state of the cardiovascular system of the person. Proposed neural network approach to the analysis of cardiosignalas. The overall objective was divided into two directions of analysis: the study of electrical and mechanical work of cardiovascular system. They used such types of kardiosignalas as electrocardiogram, cardiointervalography, pulse curve and phonocardiogram. This approach will allow evaluating the different aspects of functioning of the cardiovascular system and obtain generalizations.
Keywords: cardiography, pletismography, cardiointervalography, phonocardiography, analysis, neuron networks.
Considered are the application issues of biotechnological systems for human-engineering designing of the «cosmonaut — anthropomorphic robot» complex and studying limitations imposed by human factors in the sphere of space robotics.
Keywords: space robots, human engineering design, research stand, biotechnical system.
Discusses the distribution model of heterogeneity of electrochemical processes that describe the distribution of potential actions in excitable environment, allowing to model (in the framework of the method of cellular automat) «non-conservative» forces, dependent passed trajectory.
Keywords: distribution model heterogeneity of electrochemical processes, distribution of potential actions, cellular automat, accumulative function.
Keywords: model, identification of water ecosystems, information system, the influence of heavy metal.

Mazurov A. I., Potrahov N. N. The spatial resolution of the digital x-ray units

Reviews the issues of providing high spatial resolution of the digital x-ray systems. It is shown that the equipment of the digital x-ray diagnostic complexes microfocus emitters for targeted pictures with zoom area of interest increases their diagnostic capabilities for detection of small structures.

Keywords: digital x-ray machines, nonplanar resolution, microfocus x-ray, depth of field.

Orehov F. K., Gradov O. V. On-line compatibility of COBAC, QSPR/QSAR and SBGN technologies: the unity of theory and practice for biomedical equipment design and biochemical diagnostic data analysis

A current global trend in the development of biomedical and pharmaceutical chemistry is the use of computerized analytical technologies like COBAC, typically followed by the comparison with the action of the known analyses using QSAR/QSPR methods. The clinicians are interested not in the results of the primary measurements, but in representative results of the physiological and biochemical tests compared with the preceding drugs and their analogs. In this case a direct conversion of numerical data into the QSAR/QSPR descriptor values with their subsequent transformation.

Keywords: QSAR / QSPR, COBAC, SBGN, SPECTRAL-SAR, SCADA, GUI.

Oganesian V. A., Notchenko A. V., Gradov O. V. Mechanotronic neurogoniometer for in vivo & in situ measurements on living brain slices and operating with a stereotaxic apparatus. Preliminary report

The possibility of constructing a dynamic neurogoniometer based on rotary mechanotronic system controlled by stepper motors and a number of controlled reflectors on the galvanometric scanners is considered below. The control is performed by a PIC-controller, but there is also another low-cost construction using stepper motors control modules in a CAMAC standard. There are several designs based on a universal Feodorov stage and the apparatus for stereotaxis. The above schemes can be used both for working with the fixed histological slices and for in vivo or in situ analysis, particularly of living brain slices.

Keywords: neuronal goniometry, neurogoniometry, stepping motors, controller, CAMAC, PIC, universal stage, Feodorov stage, neuromorphogesis, electromorphology.

Gradov О. V., Yablokov A. G. Abstract phenomenological model qualimetria microsurgical tools: formal theory and metrological ideology

Briefly covers the theory and metrological ideology build abstract phenomenological model qualimetria micro-surgical tools.

Keywords: laser scanning the sample coordinate the transformation of the matrix detection, discrete cell.

Mironenko E. E. Analysis of methods MRI studies temperature fields of biological tissues

Analyzed the experimental data on the development of methods MRI thermometry in medical practice.

Keywords: magnetic resonance tomography, thermometry, biologists-economic tissues.

Taranov A. A., Spiridonov I. N. Non-contact measurement of frequency of arterial pulse

It is known that arterial pulse is one of the most frequently measured characteristics in medical practice researches. And today you can see a lot of different approaches to arterial pulse measurements (manual palpation, ultrasound research, pulseoximetry, reoplethysmog-raphy, sphygmography and etc.) But all those conventional methods demand a direct contact with patient body that is not always suitable for patients. For the instance it is not comfortable in case of long term real time measurements (which is often required in medical researches), or in case of pulse measurement on immobilized patients. But in a recent time it was shown that this problem can be solved by means of non-contact photoplethysmography and that even more interesting that such technique can be realized by means of a personal computer with web cam. Nevertheless until now you could not find this technology outside the laboratory. In this paper we introduce a novel open-source project, devoted to development of free and open source arterial pulse measurement system that provides accurate contactless measurements in a real time mode. The project is hosted as «Pulse capture» application on sourceforge.net online repository.

Keywords: non-contact measurement, frequency of arterial pulse, photoplethysmography, digital camera, software, algoritmical software.

Kotin V. V. Forecasting incidence: dynamic models and time series

Presents a method for predicting the course of human infectious diseases on the basis of the analysis of data provided by the Department of epidemiology and evidence-based medicine First of MSMU them. Sechenov. Were approved the following approaches: parametric identification SIR-models, time series analysis using exponent, adaptive methods of forecasting of time series using methods brown and Holt-winters, time series forecasting morbidity using artificial neural networks and testing neuro-fuzzy hybrid networks.

Keywords: indistrict termoporary ranks, parametrical identification, forecast of temporary ranks, neuro and indistinct network, infectious disease.

Kryuchkov В. I., Usov V. M. Special application of biotechnical systems for cosmonaut training and human engineering designing of the «man—machine—environment» complex

Baulina О. V., Istomina Т. V. The use of multi bos in sports medicine

It is shown that the use of computer stabilography the method of multiparameter biological feedback (BFB) will further increase not only the professionalism and effectiveness of the gymnasts in all phases of sports training and maximal involvement of athletes in this sport.

Keywords: computer stabiologtaphy, multiparameter bio-logical feedback (BFB), sports gymnastics.

Lebedenko I. S., Belyanskaya E. S. Use the educational process of the virtual laboratory works on modeling of functioning of the heart

Considers the issues of setting up virtual laboratory works on mathematical models of functioning of the heart.

Keywords: virtual laboratory work, mathematical models, the functioning of the heart.

Kostenkov S. Yu., Sidorova M. A. Peculiarities of simulation of electrophysiological signals

Considers the peculiarities of simulation of electrophysiological signals (EFS). To evaluate the performance of algorithms of recognition and processing of different EFS is proposed to create a database model test sequences these signals using MATLAB. This will allow to apply the developed simulator for testing and evaluation of performance of medical devices registration and analysis of parameters of EFS, and for support of educational process in the preparation of specialists of medical and technical profile.

Keywords: simulation modeling, electrophysiological signals, a database, test sequence signals, MATLAB package.

Baranov V. N., Kachalin A. S., Bochkov M. S. Development of physiotherapeutic device for laser acupuncture

A comparative analysis of different modes of heating of acupuncture points (THAT) laser radiation and proposed a new device for realization of the most effective mode. It is established, that the area of the skin, appropriate containment zone acupuncture, have a low thermal conductivity and high sensitivity to thermal irritant.

Keywords: point acupuncture, laser radiation, the effective mode area of skin, thermal conductivity, sensitivity to therminal irritant.

Korguk N. L., Indyukhin A. F., Indyukhin A. A., Kuzovlev L. V. Biotechnical system electroencephalographic screening

The method of estimation of synchronization settings of bioelectric brain activity without spectral transformations and settlement functions of coherence, which allows you to build a screening system for a short time during a medical examination determines that a child has the presence of neurological disorders and issuing recommendations towards the doctor.

Keywords: biotechnical system, synchronization of bioelectric activity of the patient, neurological screening, diagnostic automation, neurological damage.

Avdeev S. A., Bogatov N. М. Analysis of electrochemical signals in the tissues of the heart on the basis of a cellular automaton

Kleniewski А. V., Bogatov N. М., Skvortsov V. P. Computer dosimetric 3D-planning remote photon radiation therapy of malignant neoplasms brain

The method static dvuhpilonnogo irradiation with wedges, showed a more narrow and centered coverage of the tumor with a uniform distribution absolute dose on the target volume and reduction of irradiated volume of healthy tissue.

Keywords: dosimerty, 3D-plannig, remote photon therapy, oncology, absorbed dose.

Rakhmanina A. A., Sikulskaya О. М. Model of adaptive management as rehabilitation of children with disorders of central nervous system

Discuss the information system for integrated assessment of the status of children with disorders of Central nervous system, based on the method of multidimensional scaling.

Keywords: information system, integrated assessment, children with disorders of Central nervous system, method of multimensional scaling.

Yurechko M. A., Sikulskaya О. М. Dentification of the condition of aquatic ecosystems under the impact of heavy metals on the basis of the information-analytical methods

Model-based identification of aquatic ecosystems considered information system identify the status of aquatic ecosystems in the degree of influence of heavy metals.